Cellular & Molecular Imaging

First test dataset for setting up WebAtlas on BIA S3

Transmission electron microscopy (TEM) of kidney tissue from renal podocyte-specific human NADPH oxidase 5 (NOX5) transgenic mice (NOX5 pod+) and wild-type control mice, from two studies of diabetic nephropathy. (1) APX-115 study: NOX5 pod+ vs wild-type mice with high-fat-diet-induced diabetic nephropathy, evaluating the pan-NADPH oxidase inhibitor APX-115 (Lee ES et al., Free Radic Biol Med 2020;161:92-101). (2) Tau/ER-stress study: NOX5 pod+ vs wild-type mice on regular or high-fat diet, examining tau phosphorylation and endoplasmic reticulum stress (Lee ES et al., Diabetes Metab J 2025). Renal ultrastructure was examined for glomerular basement membrane thickening and slit diaphragm / podocyte foot process changes. The dataset comprises 231 TEM images (78 from the APX-115 study and 153 from the tau/ER-stress study).

Aberrant biomolecular condensates are implicated in multiple incurable neurological disorders, including Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, and DYT1 dystonia. However, the role of condensates in driving disease etiology remains incompletely understood. Here, we establish myeloid leukemia factor 2 (MLF2) as a disease-associated phase transition biomarker and develop a scalable high-content platform that identifies condensate modulators across broad chemical and genetic space. We uncover FDA-approved drugs that remodel aberrant condensate composition, validating the approach for drug discovery. A genome-wide CRISPR/Cas9 screen identifies genes linked to microcephaly and related neurodevelopmental disorders whose loss drives nuclear condensate accumulation. Machine learning resolves two phenotypic clusters: RNF26 deletion induces nuclear envelope condensates reminiscent of nuclear pore defects, whereas loss of microcephaly-associated ZNF335 drives accumulation of distinct nucleoplasmic condensates. Our study provides a scalable resource for identifying corrective modulators of aberrant condensates and establishes a link between dysregulated phase transitions and neurodevelopmental disorders.

Lepidoptera, i.e. butterflies and moths, are vital components of the global ecosystem. Project Psyche is a scientific research project established to sequence the genomes of all butterflies and moths of Europe; helping to conserve, protect and drive innovation.

Microscopy image dataset of ANX A5 in cholestasis

The Darwin Tree of Life project has the goal to sequence the genomes of 70,000 species of eukaryotic organisms in Britain and Ireland. This is a collection of photographs of the samples included in the study, provided by the National History Museum (NHM).

Transmission electron microscopy (TEM) images of pancreatic islets from male C57BL/6J mice, acquired to examine pancreatic beta-cell morphology and insulin secretory granules in a study of diet-induced obesity and weight cycling. Images are organised by animal (21181R, 21184, 21185, 21188). The dataset is associated with Winn et al., Diabetes 2022 (PMID 35802127; DOI 10.2337/db22-0161).

The Darwin Tree of Life project has the goal to sequence the genomes of 70,000 species of eukaryotic organisms in Britain and Ireland. This is a collection of photographs of the samples included in the study, provided by the National History Museum (NHM).

Large reference dataset of lightfield microscopic imaging data for diversity research of bryophytes (bryology)

A reference dataset containing macroscopic and bright-field microscopic images of 16 specimens of thallose liverworts of biological soil crusts collected in Southern Sweden and Germany