Light/fluorescence microscopy of cells & tissues, and electron/cryo-EM imaging of macromolecular structures — a metadata catalog with a durable link back to the source archive, not a hosted image gallery. These are primary research datasets (often multi-GB to multi-TB), so this platform never downloads or stores the underlying imaging data itself. Datasets already in either source archive are ingested via accession paste/CSV at /mirroring by a Continental Admin (no automated harvesting — neither source archive supports geography-filterable search); a dataset not yet in either archive can instead be submitted directly below by any node operator, for Continental Admin review. Either way, whoever submits an accession or a self-submitted dataset is the one asserting African origin — this platform does not verify it.
The Darwin Tree of Life project has the goal to sequence the genomes of 70,000 species of eukaryotic organisms in Britain and Ireland. This is a collection of photographs of the samples included in the study, provided by the National History Museum (NHM).
Aberrant biomolecular condensates are implicated in multiple incurable neurological disorders, including Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, and DYT1 dystonia. However, the role of condensates in driving disease etiology remains incompletely understood. Here, we establish myeloid leukemia factor 2 (MLF2) as a disease-associated phase transition biomarker and develop a scalable high-content platform that identifies condensate modulators across broad chemical and genetic space. We uncover FDA-approved drugs that remodel aberrant condensate composition, validating the approach for drug discovery. A genome-wide CRISPR/Cas9 screen identifies genes linked to microcephaly and related neurodevelopmental disorders whose loss drives nuclear condensate accumulation. Machine learning resolves two phenotypic clusters: RNF26 deletion induces nuclear envelope condensates reminiscent of nuclear pore defects, whereas loss of microcephaly-associated ZNF335 drives accumulation of distinct nucleoplasmic condensates. Our study provides a scalable resource for identifying corrective modulators of aberrant condensates and establishes a link between dysregulated phase transitions and neurodevelopmental disorders.
The Darwin Tree of Life project has the goal to sequence the genomes of 70,000 species of eukaryotic organisms in Britain and Ireland. This is a collection of photographs of the samples included in the study, provided by the National History Museum (NHM).
The European Reference Genome Atlas (ERGA) initiative is a pan-European scientific response to current threats to biodiversity. Reference genomes provide the most complete insight into the genetic basis that forms each species and represent a powerful resource in understanding how biodiversity functions. This is a collection of the samples included in the study, provided by COPO at Earlham Institute.
The Darwin Tree of Life project has the goal to sequence the genomes of 70,000 species of eukaryotic organisms in Britain and Ireland. This is a collection of photographs of the samples included in the study, provided by the National History Museum (NHM).
Stratum corneum nanotexture feature detection using deep learning and spatial analysis: a non-invasive tool for skin barrier assessment
BioImage Archive:S-BIAD1443 · Jen-Hung Wang (Technical University of Denmark) · Panthera leo
This repository presents an objective, quantifiable method for assessing atopic dermatitis (AD) severity. The program integrates deep learning object detection with spatial analysis algorithms to accurately calculate the density of circular nano-size objects (CNOs), termed the Effective Corneocyte Topographical Index (ECTI). The ECTI demonstrates remarkable robustness in overcoming the inherent challenges of nano-imaging, such as environmental noise and structural occlusions on the corneocyte surface, further enhancing its applicability in clinical settings.
Experimental Data for CombPlex Paper: "Escalating High-dimensional Imaging using Combinatorial Channel Multiplexing and Deep Learning"
BioImage Archive:S-BIAD873 · Leeat Keren (Weizmann Institute of Science) · Sorghum bicolor
Data for all the experiments described in our paper: "Escalating High-dimensional Imaging using Combinatorial Channel Multiplexing and Deep Learning". For further information, please refer to our paper or visit our git repository.
Link to our paper: https://www.biorxiv.org/content/10.1101/2023.09.09.556962v1
Link to our GitHub repository: https://github.com/KerenLab/CombPlex
The Darwin Tree of Life project has the goal to sequence the genomes of 70,000 species of eukaryotic organisms in Britain and Ireland. This is a collection of photographs of the samples included in the study, provided by the National History Museum (NHM).
The Darwin Tree of Life project has the goal to sequence the genomes of 70,000 species of eukaryotic organisms in Britain and Ireland. This is a collection of photographs of the samples included in the study, provided by the National History Museum (NHM).
